New lead compounds with promising biological activity are represented by CP-225,917 and CP-263,114. An approach based on an intramolecular Diels-Alder reaction for the total synthesis of these compounds is exemplified by the synthesis of racemic bicyclo[4.3.1]dec-1(9),4-dienes 2a,b from triene 1.
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Nicolaou et al. (1997) studied this question.
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