What question did this study set out to answer?

To develop a rapid and straightforward protocol for quenching carbene reactivity and eliminating toxic ruthenium byproducts from olefin metathesis reaction mixtures.

February 28, 2007Organic Letters

A Rapid and Simple Cleanup Procedure for Metathesis Reactions

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To develop a rapid and straightforward protocol for quenching carbene reactivity and eliminating toxic ruthenium byproducts from olefin metathesis reaction mixtures.
Treated reaction crude mixtures across various synthetically useful metathesis transformations with a functionalized polar isocyanide.
Evaluated the efficiency of carbene deactivation and residual metal scavenging using both first- and second-generation Grubbs catalysts.
Polar isocyanide treatment successfully removed the majority of ruthenium byproducts from diverse metathesis reaction mixtures.
Isocyanide-promoted carbene insertion rapidly destroyed the reactive catalytic center in first- and second-generation Grubbs carbenes.

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Implication

Experimental study demonstrates rapid removal of ruthenium byproducts in metathesis reactions using polar isocyanides, indicating an efficient strategy for catalyst quenching.

Cite This Study

Galan et al. (2007) studied this question.

synapsesocial.com/papers/6a93757018cdb85c6fed2f9a https://doi.org/10.1021/ol0631399

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Implication

Experimental study demonstrates rapid removal of ruthenium byproducts in metathesis reactions using polar isocyanides, indicating an efficient strategy for catalyst quenching.

A Rapid and Simple Cleanup Procedure for Metathesis Reactions

Key Points

Discussion

Implication

Cite This Study

A Rapid and Simple Cleanup Procedure for Metathesis Reactions

Key Points

Discussion

Implication

Cite This Study

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