One after the other: A novel palladium-catalyzed domino reaction consisting of an amination and a direct CH bond arylation allows for a general synthesis of annulated heterocycles starting from readily available 1,2-dichloroarenes and primary as well as secondary anilines (see scheme; Cy=cyclohexyl). This is highlighted by an efficient synthesis of the natural product murrayafoline A.
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Ackermann et al. (2007) studied this question.
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