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Epoxide desymmetrizations by bromide are very rare despite the large synthetic potential of chiral bromohydrins. Herein we present a new concept for epoxide desymmetrizations in which a bifunctional Lewis acid/ammonium salt catalyst allows for efficient enantioselective epoxide ring openings by Br-. With acetylbromide as a Br- source bromohydrin esters are formed.
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Broghammer et al. (2016) studied this question.
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