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All articles of this category Stille coupling reaction of tosylamide 4 with tributyl(vinyl)tin gave directly tricyclic compound 5 in moderate yield. Deprotection of 5 led to novel azakynurenic acid 5a which showed affinity to the glycine binding site of the NMDA receptor. Stille reaction - NMDA-glycine antagonist - tricyclic azakynurenic acid
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Hume et al. (1997) studied this question.
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