The drugs did not kill the worms.When placed in drug-free medium all affected worms recovered in half to two hours.In view of the similarities observed between the drug effects of piperazine against A. lumbricoides from the pig, in vitro, and clinical use of piperazine citrate against ascariasis in man, the relationship between the beginning of drug action, duration of narcosis, rate of drug excretion, and the intestinal emptying time of the host is discussed.
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Howard G. Hanley (1955) studied this question.