Key result
Contraction and relaxation are physiologically coupled in a hyperbolic relation (r=0.79, p<0.001), which is maintained despite interventions like beta-blockers or digitalis.
Why the study?
Are contraction and relaxation coupled in patients with and without congestive heart failure, and do pharmacological interventions alter this coupling?
Population
42 subjects with and without congestive heart failure undergoing sequential digital ventriculography and…
Comparison
Graded doses of nitroprusside, 3 months of… vs Baseline measurements before intervention.
Design
Cohort
Follow-up
Up to 3 months (for beta-blockade group)
Authors
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Supports contraction-relaxation coupling in HF despite interventions; hypothesis-generating and should not yet change practice.
Observational (n=42)
Are contraction and relaxation coupled in patients with and without congestive heart failure, and do pharmacological interventions alter this coupling?
Effect estimate: r = 0.79
p-value: p=<0.001
Contraction and relaxation are physiologically coupled in a hyperbolic relationship that is maintained despite interventions with beta-blockers or digitalis.
Eichhorn et al. (1992) conducted an observational in Congestive heart failure (n=42). Pharmacological interventions (nitroprusside, beta-blockers, deslanoside) vs. Baseline was evaluated on Hyperbolic relation between contractility (Ees) and relaxation (R) (r = 0.79, p=<0.001). Contraction and relaxation are physiologically coupled in a hyperbolic relation (r=0.79, p<0.001), which is maintained despite interventions like beta-blockers or digitalis.
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