Key result
Among hospitalized neonates, rotavirus was detected in 34% of participants, revealing a shift in circulating strains with an emerging preponderance of the G12P[11] genotype alongside higher acquisition risks in low-cost facilities.
Why the study?
Rotavirus infection in neonates is generally nosocomial and difficult to control, with few studies reporting asymptomatic infection in this population.
Cross-Sectional (n=523)
Yes
The study documents a shift in circulating rotavirus genotypes among hospitalized neonates in India, highlighting the emergence of G12P[11] and the need for continuous surveillance.
Answers are grounded in this paper and cite their sources.
High asymptomatic RV detection in hospitalized neonates signals infection-control gaps; leaves open optimal screening and prevention strategies.
In neonates, rotavirus (RV) infection is generally nosocomial. The control of rotaviral infection within hospital settings is challenging due to prolonged shedding of the virus and contamination of the surrounding environment. There are few studies that have reported asymptomatic infection within neonates. In this study, neonates were screened for RV infection and possible clinical manifestations that may play a role in RV acquisition were analysed. Stool samples were collected from 523 hospitalized neonates admitted for > 48 h in a low-cost and higher-cost tertiary centre. RV antigen was screened using ELISA and the samples which tested positive were confirmed by semi-nested RT-PCR. RV was detected in 34% of participants and genotypes identified included G12P[11] (44.4%), G10 P[11] (42.6%), G10G12P[11] (10.1%) and G3P[8] (2.9%). ICU admissions were associated with higher viral shedding (p < 0.05). Hospitalization in the low-cost facility ICU was associated with higher RV acquisition risk (p < 0.05). RV was detected in higher rates (36.9%) among neonates with gastrointestinal manifestations. G10P[11] was the predominant genotype for several years (1988-2016) among neonates within India. The preponderance of an emerging G12P[11] genotype and heterotypic distribution was documented. RV surveillance is important to identify emerging strains and establish the road ahead in managing RV infection.
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Reju et al. (2022) conducted a cross-sectional in Rotavirus infection (n=523). Hospitalization in low-cost facility vs. Hospitalization in high-cost facility was evaluated on Rotavirus detection rate (p=<0.05). Among hospitalized neonates, rotavirus was detected in 34% of participants, revealing a shift in circulating strains with an emerging preponderance of the G12P[11] genotype alongside higher acquisition risks in low-cost facilities.
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