Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Reviews in Medical Virology

Impact of Rotavac Vaccine on Hospital‐Based Disease Prevalence and Strain Diversity in India: A Systematic Review and Meta‐Analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

KSKasturi SaikiaRARuhi AhmedBDBimal Kumar Das

Discussion

Loading...

Member takes

Overview

Systematic review shows decreased rotavirus prevalence in children, suggesting vaccination effectiveness in India.

Key Points

  • Rotavirus vaccination reduced the prevalence of gastroenteritis from 33% to 23%, indicating vaccine effectiveness.
  • The study found a shift in dominant genotypes post-vaccination with G1 and G3 becoming more prevalent.
  • Analysis used a DerSimonian-Laird random-effects model in a systematic review with 49 eligible studies.
  • The findings highlight the need for ongoing surveillance to monitor emerging rotavirus strains and inform future vaccine policies.

Cite This Study

Saikia et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd2a54b1d3bfb60ee164https://doi.org/10.1002/rmv.70066
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular epidemiology of rotavirus causing diarrhea among under-five children after the introduction of rotavirus vaccines, Rotavac and Rotasiil, into the national immunization program of India2026 · 1 citations
  2. 2Rotavirus diversity among diarrheal children in Delhi, India during 2007–20122014 · 41 citations
  3. 3Dynamics of G2P[4] strain evolution and rotavirus vaccination: A review of evidence for Rotarix2020 · 34 citations
  4. 4Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis2024 · 6 citations
  5. 5Prevalence, Pattern and Genetic Diversity of Rotaviruses among Children under 5 Years of Age with Acute Gastroenteritis in South Africa: A Systematic Review and Meta-Analysis2021 · 23 citations