Why the study?
Rotavirus is the leading cause of severe acute gastroenteritis in children under 5 worldwide, with sub-Saharan Africa bearing a major burden of diarrheal deaths.
Does rotavirus vaccine introduction change the prevalence and genotype diversity of rotavirus infection in children under 5 with acute gastroenteritis in South Africa?
Population
43 eligible studies of children under 5 years of age with acute gastroenteritis in South Africa
Comparison
Pre-vaccination period vs post-vaccination period
Design
Systematic review and meta-analysis
Authors
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Stable rotavirus prevalence post-vaccination; leaves open long-term effects of genotype replacement requiring continued surveillance.
Does rotavirus vaccine introduction change the prevalence and genotype diversity of rotavirus infection in children under 5 with acute gastroenteritis in South Africa?
Rotavirus vaccine introduction in South Africa was associated with a slight reduction in overall rotavirus prevalence but a significant shift in genotype diversity, highlighting the need for ongoing surveillance.
Omatola et al. (2021) studied this question.
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