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August 5, 2010The Journal of Infectious Diseases

Characterization and Molecular Epidemiology of Rotavirus Strains Recovered in Northern Pretoria, South Africa during 2003–2006

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Population

729 rotavirus-positive stool specimens from children <5 years of age treated for diarrhea at Dr George…

Design

Cross-sectional

Follow-up

2003-2006

Authors

MSMapaseka SeheriNPNicola PageJDJohn Barr Dewar

Discussion

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Overview

Rotavirus strain variation and P[6] prevalence in South Africa may affect vaccine performance; leaves open need for genotype-specific efficacy surveillance.

Structured PICO

P
Population
729 rotavirus-positive stool specimens from children <5 years of age treated for diarrhea at Dr George Mukhari Hospital, Ga-Rankuwa, South Africa
O
Outcome
Molecular characterization and genotyping of rotavirus strains (VP4 and VP7 alleles)surrogate

The study highlights the significant diversity and annual variation of circulating rotavirus strains in South Africa, which is important for evaluating vaccine efficacy.

Cite This Study

Seheri et al. (2010) studied this question.

synapsesocial.com/papers/6a6fb0dffebe604dd7088db9https://doi.org/10.1086/653559
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Further characterization of field strains of rotavirus from Nigeria VP4 genotype P6 most frequently identified among symptomatically infected children1997 · 38 citations
  2. 2Characterization of rotavirus strains from newborns in New Delhi, India1994 · 466 citations
  3. 3Phylogenetic analysis of rotaviruses with predominant G3 and emerging G9 genotypes from adults and children in Wuhan, China2008 · 46 citations
  4. 4Polymerase chain reaction amplification and typing of rotavirus nucleic acid from stool specimens1990 · 1,581 citations
  5. 5A Rotavirus Vaccine for Prophylaxis of Infants Against Rotavirus Gastroenteritis2004 · 167 citations