Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 2020VaccineOpen Access

Dynamics of G2P4 strain evolution and rotavirus vaccination: A review of evidence for Rotarix

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Recent temporary increases in the relative prevalence of G2P[4] rotavirus strains have been observed in countries implementing rotavirus vaccination, prompting an examination of rotavirus genotype evolution under mass vaccination with Rotarix.

Does mass vaccination with Rotarix influence the evolution and prevalence of the G2P[4] rotavirus strain?

Design

Literature review

Authors

GBGyneth Lourdes BiberaJCJing ChenPPPriya Pereira

Discussion

Loading...

Member takes

Overview

RV vaccines reduce severe childhood gastroenteritis; review confirms impact but leaves open recent increases' implications.

Structured PICO

Does mass vaccination with Rotarix influence the evolution and prevalence of the G2P[4] rotavirus strain?

P
Population
Populations in countries with and without rotavirus vaccination programs
I
Intervention
Rotavirus vaccination (specifically Rotarix)
C
Comparator
No vaccination, RotaTeq, or mixed vaccination programs
O
Outcome
Rotavirus genotype evolution and relative prevalence of G2P[4] strains

Rotavirus strain fluctuations, including G2P[4], appear to be natural evolutionary processes rather than vaccine-escape phenomena, and current vaccines remain effective.

Cite This Study

Bibera et al. (2020) studied this question.

synapsesocial.com/papers/6a6fb0e2febe604dd7088dcehttps://doi.org/10.1016/j.vaccine.2020.06.059
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome-Wide Evolutionary Analyses of G1P[8] Strains Isolated Before and After Rotavirus Vaccine Introduction2015 · 51 citations
  2. 2Serotype Diversity and Reassortment between Human and Animal Rotavirus Strains: Implications for Rotavirus Vaccine Programs2005 · 630 citations
  3. 3Distribution of rotavirus G and P genotypes approximately two years following the introduction of rotavirus vaccines in South Korea2013 · 11 citations
  4. 4Molecular characterisation of the NSP4 gene of group A human rotavirus G2P[4] strains circulating in São Paulo, Brazil, from 1994 and 2006 to 20102015 · 4 citations
  5. 5Rotavirus Strain Types Circulating in Africa: Review of Studies Published during 1997–20062010 · 170 citations