Key result
Lidocaine successfully interrupted ventricular fibrillation following coronary occlusion in dogs with rare recurrence and no obvious sequelae, though success was lower in hypothermic animals.
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Hypothesis-generating for lidocaine in ischemic VF models; leaves open translation to clinical or hypothermic settings.
The interruption of ventricular fibrillation following coronary occlusion in dogs was effected with the use of lidocaine. This technic caused no obvious sequelae and the recurrence of fibrillation was rare. It was used successfully in both normothermic and hypothermic animals although the proportion of successful resuscitations was less in the latter group.
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CARDEN et al. (1956) studied this question. Lidocaine successfully interrupted ventricular fibrillation following coronary occlusion in dogs with rare recurrence and no obvious sequelae, though success was lower in hypothermic animals.
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