Azidothymidine (AZT) has been used for treatment of acquired immunodeficiency syndrome (AIDS), but a recent concord trial showed that it is ineffective for suppressing the development of AIDS. In this study, the effects of AZT on three cell lines transformed by pCD12 plasmid (human immunodeficiency virus-1 (HIV-1) promoter-chloramphenicol acetyltransferase) were examined. Results showed that AZT has the potential to activate the HIV-1 promoter.
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Shun‐ichi Kurata (1994) studied this question.
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