Key result
Diabetic autonomic neuropathy had no effect on glucagon and metabolic responses to insulin-induced hypoglycemia in juvenile, insulin-treated diabetics.
Why the study?
Does diabetic autonomic neuropathy affect glucagon and metabolic responses to insulin-induced hypoglycemia in juvenile diabetics?
Observational (n=14)
Does diabetic autonomic neuropathy affect glucagon and metabolic responses to insulin-induced hypoglycemia in juvenile diabetics?
Diabetic autonomic neuropathy does not appear to affect glucagon and metabolic responses to hypoglycemia in juvenile, insulin-treated diabetics.
Answers are grounded in this paper and cite their sources.
No effect on counterregulation does not warrant neuropathy-specific hypoglycemia protocols in juvenile diabetics; leaves open mechanisms in prospective studies.
Glucagon and metabolic responses to insulin-induced hypoglycemia were studied in seven juvenile diabetics, age 31 +/- 2 years (mean and S.E.M.), duration of diabetes 17 +/- 3 years, with diabetic autonomic neuropathy (decreased beat-to-beat variation in heart rate during hyperventilation and/or orthostatic hypotension) and in seven control patients of similar age and duration of diabetes with out neuropathy. Before the hypoglycaemic episode, normoglycemia had been maintained for at least 10 hours. Following hypoglycemia, a slight but significant and similar increase in plasma glucagon was found in both patient groups. Metabolic responses to hypoglycemia were also similar in the two patient groups. In conclusion, diabetic autonomic neuropathy has no effect on glucagon and metabolic responses to hypoglycemia in juvenile, insulin-treated diabetics.
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Hilsted et al. (1980) conducted an observational in Juvenile diabetes (n=14). Diabetic autonomic neuropathy vs. Juvenile diabetics without autonomic neuropathy was evaluated on Glucagon and metabolic responses to insulin-induced hypoglycemia. Diabetic autonomic neuropathy had no effect on glucagon and metabolic responses to insulin-induced hypoglycemia in juvenile, insulin-treated diabetics.
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