Key result
Early surgery for aneurysmal subarachnoid hemorrhage did not significantly reduce the risk of poor outcome compared to intermediate treatment (RR 0.86; 95% CI 0.68-1.09).
Why the study?
Does early surgery improve outcomes in patients with aneurysmal subarachnoid hemorrhage compared to intermediate or late surgery?
Population
16,793 participants with aneurysmal subarachnoid hemorrhage pooled from 1 RCT and 33 observational studies
Comparison
Early surgery vs Intermediate or late surgery
Design
Meta-analysis
Authors
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Does not support early over intermediate surgery as standard; leaves open age-specific timing effects in aneurysmal subarachnoid hemorrhage.
Meta-Analysis (n=16,793)
Does early surgery improve outcomes in patients with aneurysmal subarachnoid hemorrhage compared to intermediate or late surgery?
Relative Risk: 0.86 (95% CI 0.68–1.09)
Timing of surgery for aneurysmal subarachnoid hemorrhage does not significantly impact overall surgical outcome, though early intervention may offer benefits in specific age subgroups.
Zhao et al. (2015) conducted a meta-analysis in Aneurysmal subarachnoid hemorrhage (aSAH) (n=16,793). Early surgery vs. Intermediate or late surgery was evaluated on Poor outcome (RR 0.86, 95% CI 0.68-1.09). Early surgery for aneurysmal subarachnoid hemorrhage did not significantly reduce the risk of poor outcome compared to intermediate treatment (RR 0.86; 95% CI 0.68-1.09).
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