Key result
Intravenous clonidine had no effect on the markedly elevated rate of norepinephrine spillover to, or clearance from, plasma in patients during the first week after subarachnoid hemorrhage.
Why the study?
Does intravenous clonidine reduce sympathetic nervous activation (norepinephrine spillover) in patients with subarachnoid hemorrhage?
Population
25 patients with subarachnoid hemorrhage, compared with 17 healthy age-matched subjects and 8 patients with…
Comparison
Clonidine continuous i.v. infusion 5.8 +/- 0.7… vs Standard therapy
Design
Cohort
Follow-up
first week after subarachnoid hemorrhage
Authors
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Clonidine does not reduce norepinephrine spillover after subarachnoid hemorrhage; leaves open alternative sympathetic targets for prospective study.
Observational (n=50)
Does intravenous clonidine reduce sympathetic nervous activation (norepinephrine spillover) in patients with subarachnoid hemorrhage?
Intravenous clonidine does not reduce the markedly elevated sympathetic nervous activity (norepinephrine spillover) observed in patients following subarachnoid hemorrhage.
Lambert et al. (2002) conducted an observational in Subarachnoid hemorrhage (n=50). Intravenous clonidine vs. Standard therapy was evaluated on Rate of spillover of norepinephrine to plasma. Intravenous clonidine had no effect on the markedly elevated rate of norepinephrine spillover to, or clearance from, plasma in patients during the first week after subarachnoid hemorrhage.
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