Key result
Epidural clonidine decreased resting skin sympathetic activity to 18% (P<0.001) and muscle sympathetic activity to 41% (P<0.01) of control values, indicating a supraspinal mechanism.
Why the study?
Does epidural clonidine decrease sympathetic nerve activity via a supraspinal mechanism in healthy volunteers?
Population
21 healthy volunteers (15 for epidural clonidine, 6 for intramuscular clonidine)
Comparison
Epidural clonidine or intramuscular clonidine vs Baseline and comparison between epidural and…
Design
Other
Follow-up
30 minutes
Authors
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Suggests supraspinal sympatholysis by epidural clonidine in volunteers; hypothesis-generating and leaves open clinical translation.
Does epidural clonidine decrease sympathetic nerve activity via a supraspinal mechanism in healthy volunteers?
p-value: p=<0.001
Epidural clonidine induces a supraspinally evoked general decrease in sympathetic outflow, comparable to intramuscular administration.
Kirnö et al. (1993) studied Healthy volunteers (n=21). Clonidine vs. Baseline (control values) was evaluated on Resting level of skin and muscle sympathetic activity (p=<0.001). Epidural clonidine decreased resting skin sympathetic activity to 18% (P<0.001) and muscle sympathetic activity to 41% (P<0.01) of control values, indicating a supraspinal mechanism.
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