Key result
Thoracic intrathecal clonidine injection (100 or 300 micrograms) decreased blood pressure in conscious sheep, whereas injection at other sites did not affect blood pressure at these doses.
The hemodynamic effects of intrathecal alpha 2-adrenergic agonists are dependent on the site of injection, drug dose, and drug lipophilicity, which may be exploited to minimize hemodynamic depression.
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Site-dependent BP effects of intrathecal clonidine in sheep are hypothesis-generating; human relevance and safety require prospective study.
Eisenach et al. (1991) studied this question. Intrathecal clonidine vs. Different injection sites (cervical, thoracic, lumbar) was evaluated on Blood pressure changes. Thoracic intrathecal clonidine injection (100 or 300 micrograms) decreased blood pressure in conscious sheep, whereas injection at other sites did not affect blood pressure at these doses.
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