Key result
Clonidine acts rostral to the pons to decrease ACTH and increase growth hormone, whereas it acts on the medulla or adjacent hindbrain to lower blood pressure.
Why the study?
Does clonidine administered via different routes affect blood pressure, renin, growth hormone, and ACTH secretion differently in pentobarbital-anesthetized dogs?
Population
pentobarbital-anesthetized dogs
Comparison
Clonidine 2 microgram/kg infused into the… vs Different routes of administration and conditions
Design
Preclinical
Authors
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Preclinical clonidine findings in dogs should not guide human use; leaves open translation of site-specific central actions.
Does clonidine administered via different routes affect blood pressure, renin, growth hormone, and ACTH secretion differently in pentobarbital-anesthetized dogs?
Clonidine acts rostral to the pons to decrease ACTH and increase growth hormone, whereas it acts on the medulla or adjacent hindbrain to lower blood pressure.
Rudolph et al. (2008) studied Pentobarbital-anesthetized dogs. Clonidine vs. Different routes of administration (intravenous, intracarotid, intravertebral) was evaluated on Blood pressure, renin secretion, ACTH secretion, and growth hormone secretion. Clonidine acts rostral to the pons to decrease ACTH and increase growth hormone, whereas it acts on the medulla or adjacent hindbrain to lower blood pressure.
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