Population
Chloralose-anesthetized and ventilated rats
Design
Preclinical
Authors
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Rules out essential role for bulbospinal catecholaminergic neurons in clonidine action; leaves open primary central sympatholytic targets in intact systems.
Bulbospinal catecholaminergic neurons are not essential for the sympatholytic and hypotensive effects of systemically administered clonidine.
Schreihofer et al. (2000) studied this question.
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