June 26, 2003Journal of Cardiovascular Pharmacology

Role of I1-Imidazoline Receptors Within the Caudal Ventrolateral Medulla in Cardiovascular Responses to Clonidine in Rats

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Population

Male Sprague-Dawley rats anesthetized with urethane

Design

Preclinical

Authors

WWWeizhong WangCross-Cutting Cardiology WYWen-Jun YuanBeijing University of Chemical Technology ARAn‐Jing RenNaval Medical Research Command

Discussion

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Implication

Supports I1 receptor mediation of clonidine in rat CVLM; leaves open translation to human hypertension therapy.

Structured PICO

Population

Male Sprague-Dawley rats anesthetized with urethane

Intervention

Microinjection of clonidine (6 nmol/50 nl), yohimbine (500 pmol/50 nl), or idazoxan (2 nmol/50 nl or 4 nmol/100 nl) into the caudal ventrolateral medulla, and intravenous clonidine (5 and 50 microg/kg)

Outcome

Blood pressure, heart rate, and discharge of the rostral ventrolateral medulla presympathetic neuronssurrogate

I1-imidazoline receptors in the caudal ventrolateral medulla play a key role in maintaining tonic cardiovascular activities and mediating the antihypertensive effects of systemic clonidine in rats.

Cite This Study

Wang et al. (2003) studied this question.

synapsesocial.com/papers/6a8544e9f2bb7ee68cf24094 https://doi.org/10.1097/00005344-200307000-00001

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Role of I1-Imidazoline Receptors Within the Caudal Ventrolateral Medulla in Cardiovascular Responses to Clonidine in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of I1-Imidazoline Receptors Within the Caudal Ventrolateral Medulla in Cardiovascular Responses to Clonidine in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider