Population
21 conscious rabbits with implanted fourth-ventricular catheters
Comparison
Central administration of efaroxan on day 9 and… vs Central administration of 2-methoxyidazoxan…
Design
Preclinical
Follow-up
3 weeks
Authors
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Supports imidazoline receptor mediation in this animal model; leaves open applicability to human hypertension treatment.
The hypotensive effects of chronic moxonidine, rilmenidine, and clonidine are mediated predominantly via central imidazoline receptors rather than alpha2-adrenoceptors.
Parkin et al. (2003) studied this question.
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