Key result
Moxonidine effectively lowers systolic blood pressure by 20-30 mm Hg and diastolic by 10-20 mm Hg, providing similar blood pressure control to other major antihypertensive classes.
Why the study?
Does moxonidine effectively reduce blood pressure compared to other antihypertensive agents in patients with hypertension?
Population
Patients with hypertension (including male and female subjects, age <50, 50-60, and >60 years old)
Comparison
Moxonidine (typically 0.2-0.4 mg daily oral) vs Other antihypertensive classes including…
Design
Review
Authors
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Moxonidine acutely lowers BP and SVR without affecting EF; extends meta-analytic support for central I1-receptor agonism in hypertension.
Does moxonidine effectively reduce blood pressure compared to other antihypertensive agents in patients with hypertension?
Moxonidine is an effective centrally-acting antihypertensive agent that provides comparable blood pressure reduction to other major drug classes with a favorable side effect profile compared to clonidine.
Prichard et al. (1996) conducted a review in Hypertension. Moxonidine vs. Other antihypertensive drugs (diuretics, clonidine, calcium antagonists, ACE inhibitors, alpha- and beta-blockers) was evaluated on Blood pressure reduction. Moxonidine effectively lowers systolic blood pressure by 20-30 mm Hg and diastolic by 10-20 mm Hg, providing similar blood pressure control to other major antihypertensive classes.
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