Population
Rats anaesthetized with urethane
Comparison
Intravenous administration of rilmenidine (30… vs Comparison between rilmenidine/moxonidine and…
Design
Preclinical
Authors
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Challenges I1 selectivity hypothesis in animal sympatholysis; leaves open translation to human hypertension management.
Rilmenidine and moxonidine inhibit cerebrocortical noradrenaline release similarly to clonidine and guanabenz, challenging the hypothesis that their I1 selectivity prevents suppression of central noradrenergic neurons.
Szabó et al. (2001) studied this question.
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