July 15, 2004Journal of Hypertension
Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion
Why the study?
Does rilmenidine reduce sympathetic activity and blood pressure at rest and during reflex sympathetic activation in hypertensive patients?
Population
15 hypertensive patients
Comparison
Rilmenidine 1 mg twice daily for 2 weeks vs Placebo for 2 weeks
Design
RCT, randomized, double-blind
Follow-up
2-week treatment intervals
Authors
Discussion
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Member takes
Implication
Supports rilmenidine for resting BP control via sympatholysis; extends evidence that central agents preserve reflex sympathetic activation.
Structured PICO
Does rilmenidine reduce sympathetic activity and blood pressure at rest and during reflex sympathetic activation in hypertensive patients?
P
Population
15 hypertensive patients
I
Intervention
Rilmenidine 1 mg twice daily for 2 weeks
C
Comparator
Placebo for 2 weeks
O
Outcome
Noradrenaline and adrenaline plasma kinetics and intra-arterial blood pressure measurements at rest, after mental stress, and during head-up tiltingsurrogate
Rilmenidine effectively lowers resting sympathetic activity and blood pressure in hypertensive patients without blunting normal physiological sympathetic responses to stress or posture.
Cite This Study
Esler et al. (2004) studied this question.