Key result
Rilmenidine produced a dose-dependent decrease in blood pressure without increasing heart rate, enhanced parasympathetic tone, and reduced sympathetic tone in healthy male volunteers.
Why the study?
Does rilmenidine affect autonomic function in healthy male volunteers?
Population
6 healthy male volunteers
Design
Other
Authors
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Supports autonomic effects of rilmenidine in healthy volunteers; leaves open translation to hypertensive patients.
Does rilmenidine affect autonomic function in healthy male volunteers?
Rilmenidine lowers blood pressure while modulating autonomic function by enhancing parasympathetic tone and reducing sympathetic tone.
McKaigue et al. (1992) studied Healthy (n=6). Rilmenidine was evaluated on Autonomic function tests (baroreflex function, reflex cardiovascular responses). Rilmenidine produced a dose-dependent decrease in blood pressure without increasing heart rate, enhanced parasympathetic tone, and reduced sympathetic tone in healthy male volunteers.
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