Key result
Intravenous rilmenidine inhibited the RSNA baroreflex range by 33%, an effect reversed by idazoxan and 2-MI, indicating mediation via imidazoline receptors and alpha2-adrenoceptors in the RVLM.
Population
Urethane anaesthetized rabbits
Comparison
Intravenous rilmenidine with subsequent… vs Baseline (before microinjection into the RVLM)
Design
Preclinical
Authors
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Rilmenidine's RVLM-mediated sympathoinhibition is hypothesis-generating; leaves open translation to human hypertension and receptor-selective therapies.
The hypotensive and sympatho-inhibitory actions of systemic rilmenidine are primarily mediated via imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla.
Chan et al. (2006) studied this question. Rilmenidine vs. Baseline (before microinjection) was evaluated on Renal sympathetic nerve activity (RSNA) baroreflex range. Intravenous rilmenidine inhibited the RSNA baroreflex range by 33%, an effect reversed by idazoxan and 2-MI, indicating mediation via imidazoline receptors and alpha2-adrenoceptors in the RVLM.
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