Population
7 conscious normotensive rabbits, chronically instrumented with a fourth ventricular catheter, aortic and…
Design
Preclinical
Authors
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Animal data on rilmenidine's receptor preference warrant no clinical change; leaves open translation to human central antihypertensives.
In conscious rabbits, activation of imidazoline receptors is more important than alpha2-adrenoceptors for the renal sympathoinhibitory action of the centrally acting antihypertensive drug rilmenidine.
Head et al. (2001) studied this question.
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