Key result
Rilmenidine lowered mean arterial pressure to near normotensive levels and reduced MAP variability and RSNA in hypertensive rabbits, minimizing reflex autonomic disturbances.
Why the study?
Does rilmenidine modify renal sympathetic nerve activity and heart rate baroreflexes during stress in conscious renovascular hypertensive rabbits?
Population
Conscious rabbits made hypertensive with a renal-artery clip
Comparison
Rilmenidine and airjet stress vs Normotensive sham rabbits and baseline…
Design
Preclinical
Follow-up
3 weeks
Authors
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Rilmenidine may attenuate autonomic disturbances in hypertension; leaves open translation to human baroreflex modulation.
Does rilmenidine modify renal sympathetic nerve activity and heart rate baroreflexes during stress in conscious renovascular hypertensive rabbits?
Rilmenidine effectively minimizes reflex autonomic disturbances produced by hypertension and stress in a rabbit model of renovascular hypertension.
Burke et al. (2008) studied Renovascular hypertension. Rilmenidine vs. Normotensive/sham rabbits and pre-treatment baseline was evaluated on Renal sympathetic nerve activity (RSNA) and heart rate (HR) baroreflexes. Rilmenidine lowered mean arterial pressure to near normotensive levels and reduced MAP variability and RSNA in hypertensive rabbits, minimizing reflex autonomic disturbances.
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