Why the study?
Do imidazoline-preferring drugs lower blood pressure with fewer centrally mediated side effects compared to traditional centrally acting antihypertensives?
Population
Normal subjects (n=9) and patients with essential hypertension
Comparison
Imidazoline-preferring drugs vs Clonidine 0.1 mg orally, atenolol, and placebo
Design
Review, Double-blind (for the rilmenidine study)
Follow-up
4 weeks (for the rilmenidine study)
Authors
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May favor imidazoline agents in sedation-prone patients; leaves open prospective head-to-head confirmation.
Do imidazoline-preferring drugs lower blood pressure with fewer centrally mediated side effects compared to traditional centrally acting antihypertensives?
Imidazoline-preferring drugs offer an effective antihypertensive therapy with a more favorable side effect profile regarding sedation and psychomotor impairment compared to traditional centrally acting agents.
Reid et al. (1995) studied this question.
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