July 1, 1996Journal of Hypertension

Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine

View Full Paper

Ask AI

Bookmark

Population

14 conscious rabbits (6 for dose-response studies, 8 with implanted fourth-ventricular catheters)

Comparison

Intravenous moxonidine, rilmenidine, and… vs Comparison between the antihypertensive agents…

Design

Preclinical

Authors

CCCandy K.S. ChanBaker Heart and Diabetes Institute GHGeoffrey A. HeadPreventive Cardiology

Discussion

Member takes

Implication

Supports imidazoline receptor mediation in animals; leaves open clinical differentiation from clonidine in hypertension.

Structured PICO

Population

14 conscious rabbits (6 for dose-response studies, 8 with implanted fourth-ventricular catheters)

Intervention

Intravenous moxonidine, rilmenidine, and clonidine, followed by central administration of efaroxan (an I1-imidazoline/alpha 2-adrenoceptor antagonist) or 2-methoxyidazoxan (an alpha 2-adrenoceptor antagonist)

Comparator

Comparison between the antihypertensive agents and the two antagonists (efaroxan vs 2-methoxyidazoxan)

Outcome

Mean arterial pressure and heart rate (hypotension and bradycardia)surrogate

Moxonidine and rilmenidine lower blood pressure primarily via central imidazoline receptors, unlike clonidine which acts predominantly on central alpha-2 adrenoceptors.

Cite This Study

Chan et al. (1996) studied this question.

synapsesocial.com/papers/6a86dc6336c36f97809ebcd9 https://doi.org/10.1097/00004872-199607000-00008

View Full Paper

Ask AI

Bookmark

Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider