Key result
Experimental subarachnoid hemorrhage in dogs induced regional wall motion abnormalities in 88.9% vs 20.0% of controls (P=0.02), occurring in the absence of myocardial hypoperfusion.
Why the study?
Does experimental subarachnoid hemorrhage induce cardiac injury in the absence of myocardial hypoperfusion in a canine model?
Population
14 dogs (9 with experimental subarachnoid hemorrhage and 5 controls)
Comparison
Experimental subarachnoid hemorrhage (SAH) vs Control dogs without experimental SAH
Design
Preclinical
Authors
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Neurogenic mechanisms may drive post-subarachnoid hemorrhage cardiomyopathy; hypothesis-generating in dogs and leaves open human translation.
Does experimental subarachnoid hemorrhage induce cardiac injury in the absence of myocardial hypoperfusion in a canine model?
Absolute Event Rate: 88.9% vs 20%
p-value: p=0.02
In a canine model of subarachnoid hemorrhage, regional left ventricular dysfunction occurs without myocardial hypoperfusion, suggesting alternative mechanisms for cardiac injury.
Zaroff et al. (2000) studied Subarachnoid hemorrhage (n=14). Experimental subarachnoid hemorrhage vs. Controls was evaluated on Regional wall motion abnormalities (p=0.02). Experimental subarachnoid hemorrhage in dogs induced regional wall motion abnormalities in 88.9% vs 20.0% of controls (P=0.02), occurring in the absence of myocardial hypoperfusion.
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