What question did this study set out to answer?

To evaluate the in vivo effect of growth hormone replacement on human chorionic gonadotropin-stimulated testicular response in patients with combined gonadotropin and growth hormone deficiencies.

January 1, 1993European Journal of Endocrinology

The effect of growth hormone administration on testicular response during gonadotropin therapy in subjects with combined gonadotropin and growth hormone deficiencies

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Authors

RBRina BalducciUniversity of Rome Tor Vergata VTVincenzo ToscanoUniversity of Milan AMA. MangiantiniUniversity of Rome Tor Vergata

Discussion

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Implication

Clinical study demonstrates enhanced testicular response to gonadotropins during growth hormone therapy in hormone-deficient males, indicating growth hormone augments testicular steroidogenesis.

Key Points

To evaluate the in vivo effect of growth hormone replacement on human chorionic gonadotropin-stimulated testicular response in patients with combined gonadotropin and growth hormone deficiencies.
Studied 4 hypogonadotropic males (aged 18–19 years) with coexisting growth hormone deficiency receiving hCG (1,500 IU every 6 days) and FSH (75 IU every 3 days).
Measured testicular steroid response curves before and 2, 4, and 6 days following hCG administration during GH treatment (4 IU thrice weekly) and 6 months after GH withdrawal.
Quantified area under the response curve (AUC) for testosterone, androstenedione, 17 alpha-hydroxyprogesterone, and estradiol.
Testosterone AUC was significantly higher during GH therapy than after GH withdrawal (2993 ± 1091 vs 2310 ± 751; p < 0.04).
Androstenedione AUC was significantly increased during GH therapy (708 ± 377 vs 402 ± 248; p < 0.05), whereas 17 alpha-hydroxyprogesterone AUC was significantly lower (235 ± 190 vs 542 ± 307; p < 0.05).
Estradiol AUC showed no statistically significant difference between the GH treatment and withdrawal periods (22,860 ± 10,082 vs 25,697 ± 13,640).

Cite This Study

Balducci et al. (1993) studied this question.

synapsesocial.com/papers/6a938f8887f8000eec56a629 https://doi.org/10.1530/acta.0.1280019

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Implication

Clinical study demonstrates enhanced testicular response to gonadotropins during growth hormone therapy in hormone-deficient males, indicating growth hormone augments testicular steroidogenesis.

The effect of growth hormone administration on testicular response during gonadotropin therapy in subjects with combined gonadotropin and growth hormone deficiencies

Discussion

Member takes

Implication

Key Points

Cite This Study

The effect of growth hormone administration on testicular response during gonadotropin therapy in subjects with combined gonadotropin and growth hormone deficiencies

Discussion

Member takes

Implication

Key Points

Cite This Study

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