What question did this study set out to answer?

To investigate the effects of 6 months of growth hormone therapy on adrenal steroidogenesis and ACTH responsiveness in non-GH-deficient girls with Turner syndrome.

January 1, 1998Hormone Research in Paediatrics

Effects of Long-Term Growth Hormone Therapy on Adrenal Steroidogenesis in Turner Syndrome

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Authors

RBR BalducciUniversity of Rome Tor Vergata VTVincenzo ToscanoSapienza University of Rome DLDaniela LarizzaUniversity of Pavia

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Implication

Clinical study demonstrates increased adrenal androgen responsiveness to ACTH after growth hormone in girls with Turner syndrome, suggesting altered enzyme activity or receptor sensitivity.

Key Points

To investigate the effects of 6 months of growth hormone therapy on adrenal steroidogenesis and ACTH responsiveness in non-GH-deficient girls with Turner syndrome.
Studied 9 girls with Turner syndrome (chronological age 5.5–7.2 years, bone age 5–7 years) receiving growth hormone therapy at 1 IU/kg/week for 6 months.
Performed ACTH tests (0.25 mg Synacthen depot i.v., sampled at 0 and 60 minutes) at baseline and 6 months post-treatment, comparing results against two age-matched healthy control groups (A and B).
Quantified serum 17PGN, 17OHP, DHA, DHA-S, androstenedione, and cortisol levels via radioimmunoassay, setting significance at p < 0.01.
Basal DHA-S increased significantly after 6 months of growth hormone therapy from 1.57 ± 0.31 to 1.89 ± 0.43 µmol/L (p < 0.01), whereas basal 17PGN, 17OHP, DHA, androstenedione, and cortisol showed no significant differences.
Responsiveness to ACTH stimulation increased significantly for DHA (p < 0.01) and stimulated 17PGN/17OHP ratios were significantly elevated (p < 0.01), while 17OHP, androstenedione, and cortisol responses did not differ.
Post-treatment basal and stimulated DHA and stimulated 17PGN were higher in Turner syndrome patients than in age-matched controls, with no significant differences observed between the two control groups.

Cite This Study

Balducci et al. (1998) studied this question.

synapsesocial.com/papers/6a938fa604d7c7946bb849ee https://doi.org/10.1159/000023173

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Implication

Clinical study demonstrates increased adrenal androgen responsiveness to ACTH after growth hormone in girls with Turner syndrome, suggesting altered enzyme activity or receptor sensitivity.

Effects of Long-Term Growth Hormone Therapy on Adrenal Steroidogenesis in Turner Syndrome

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Implication

Key Points

Cite This Study

Effects of Long-Term Growth Hormone Therapy on Adrenal Steroidogenesis in Turner Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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