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The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism

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Prospective study demonstrates GH therapy increases adrenal androgens in adults with hypopituitarism, suggesting therapeutic implications.

This study aims to evaluate the impact of growth hormone replacement therapy on adrenal androgen secretion in adults with growth hormone deficiency.
Prospective study over 12 months involving 30 adult GH-deficient patients.
Patients classified as ACTH-sufficient or ACTH-deficient based on hormonal tests.
Serum samples collected pre-treatment and at 6 and 12 months for hormone measurement.
Serum DHEAS levels significantly increased in ACTH-sufficient patients after GH therapy (P < 0.02), while ACTH-deficient patients did not show improvement.
Median DHEAS levels rose from 1.5 µmol/L to 1.9 µmol/L in ACTH-sufficient group (32% increase, P < 0.05).
No significant changes in testosterone, A4, SHBG, or CBG levels were observed during the treatment period.

Isidori et al. (2003) studied this question.

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Prospective study demonstrates GH therapy increases adrenal androgens in adults with hypopituitarism, suggesting therapeutic implications.