Key result
The 4-methoxystyryl homologue 8 produced a significant increase in survival rate and survival time in mice infected vaginally with herpes simplex type 1.
Compound 8, a substituted benzyl beta-diketone, demonstrates significant in vitro and in vivo antiviral activity against herpes simplex viruses.
No immediate role in human HSV therapy; hypothesis-generating for beta-diketone antivirals pending clinical translation.
The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.
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Diana et al. (1977) studied Herpes simplex type 1 / RNA and DNA viruses. 4-methoxystyryl homologue 8 (substituted benzyl beta-diketone) was evaluated on Survival rate and survival time. The 4-methoxystyryl homologue 8 produced a significant increase in survival rate and survival time in mice infected vaginally with herpes simplex type 1.
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