Key result
Estrogen replacement improved functional recovery after ischemia/reperfusion compared to placebo (55.0% vs. 22.0%, P<0.05) in isolated hearts from ovariectomized rats.
Why the study?
Does estrogen improve functional recovery after ischemia/reperfusion in ovariectomized female rats?
Does estrogen improve functional recovery after ischemia/reperfusion in ovariectomized female rats?
Absolute Event Rate: 55% vs 22%
p-value: p=<0.05
Estrogen improves cardiac functional recovery after ischemia/reperfusion injury in ovariectomized rats, partly by decreasing TNFalpha levels.
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Estrogen may confer protection in ovariectomized rat hearts; leaves open translation to human postmenopausal ischemia/reperfusion injury.
Xu et al. (2006) studied Ischemia/reperfusion injury. Estrogen vs. Placebo was evaluated on Functional recovery (p=<0.05). Estrogen replacement improved functional recovery after ischemia/reperfusion compared to placebo (55.0% vs. 22.0%, P<0.05) in isolated hearts from ovariectomized rats.
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