Key result
Estrogen replacement impairs post-ischemic heart function ~51% in ovariectomized rats and stimulates fatty acid oxidation.
Why the study?
Women under 50 years, likely premenopausal and exposed to estrogen, have greater risk of poor short-term recovery after myocardial ischemia than men and older women, and the effect of estrogen on post-ischemic myocardial function and fatty acid oxidation is unclear.
Does estrogen replacement impair post-ischemic recovery and stimulate fatty acid oxidation in ovariectomized female rats?
Comparison
17beta-estradiol treatment vs corn oil vehicle in ovariectomized rats vs intact rats
Design
Preclinical experimental study
Follow-up
5 weeks
Authors
Loading...
Raises caution for estrogen in ischemic settings; hypothesis-generating and requires human validation before any clinical consideration.
Does estrogen replacement impair post-ischemic recovery and stimulate fatty acid oxidation in ovariectomized female rats?
Absolute Event Rate: 26.3% vs 53.4%
p-value: p=< 0.05
Estrogen replacement in ovariectomized rats stimulates fatty acid oxidation and impairs post-ischemic functional recovery of isolated hearts.
Grist et al. (2002) studied Myocardial ischemia (n=45). 17beta-estradiol vs. Corn oil vehicle was evaluated on Post-ischemic function relative to pre-ischemic values (p=< 0.05). Estrogen replacement in ovariectomized female rats impaired post-ischemic heart function compared to vehicle (26.3% vs 53.4%, p<0.05) and stimulated fatty acid oxidation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: