Key result
Pretreatment with alpha blocking drugs nicergoline and yohimbine failed to protect guinea pigs from daunomycin cardiotoxicity.
Why the study?
Does pretreatment with alpha blocking drugs nicergoline and yohimbine prevent daunomycin cardiotoxicity in guinea pigs?
Does pretreatment with alpha blocking drugs nicergoline and yohimbine prevent daunomycin cardiotoxicity in guinea pigs?
Alpha blocking drugs nicergoline and yohimbine do not protect against acute daunomycin-induced cardiotoxicity in a guinea pig model.
Answers are grounded in this paper and cite their sources.
Does not support alpha blockade to prevent daunomycin cardiotoxicity; hypothesis-generating in animal models, human studies needed.
The total tissue noradrenaline content of the heart from daunomycin acutely treated guinea pigs has been found to be significantly increased compared with controls. Under the same treatment, electrocardiograms showed the occurrence of alterations of electrical waves, consisting of a decrease and reversion of T waves, or an increase in their voltage. Pretreatment with alpha blocking drugs nicergoline and yohimbine failed to protect the animals from daunomycin cardiotoxicity.
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Soldani et al. (1981) studied Daunomycin cardiotoxicity. Alpha blocking drugs (nicergoline and yohimbine) vs. Controls was evaluated on Protection from daunomycin cardiotoxicity. Pretreatment with alpha blocking drugs nicergoline and yohimbine failed to protect guinea pigs from daunomycin cardiotoxicity.
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