Key result
Patients susceptible to malignant hyperthermia (n=8) had significantly lower calcium uptake capacity and (Ca2+ + Mg2+)-ATPase activity in sarcoplasmic reticulum vesicles than controls (n=8).
Case-Control (n=16)
Patients susceptible to malignant hyperthermia exhibit deficient sarcoplasmic reticulum function, characterized by reduced calcium uptake and ATPase activity, leading to increased myoplasmic free calcium.
Supports SR calcium defects in MH susceptibility; leaves open diagnostic utility pending larger validation studies.
Calcium uptake and (Ca2+ + Mg2+)-ATPase were measured in sarcoplasmic reticulum (SR) vesicles prepared from muscles of eight patients susceptible to malignant hyperthermia (MH) and eight control subjects. Intracellular resting free calcium level of some of the studied subjects was also determined. Both calcium uptake capacity and (Ca2+ + Mg2+)-ATPase activity were significantly lower in SR prepared from MH-susceptible patients than from normal subjects. Besides, in these MH-susceptible patients myoplasmic free Ca2+ was increased. These results corroborate previous suggestions that abnormal function of the SR membrane was related to the MH syndrome.
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Condrescu et al. (1987) conducted a case-control in Malignant hyperthermia (n=16). Malignant hyperthermia susceptibility vs. Control subjects was evaluated on Calcium uptake capacity and (Ca2+ + Mg2+)-ATPase activity. Patients susceptible to malignant hyperthermia (n=8) had significantly lower calcium uptake capacity and (Ca2+ + Mg2+)-ATPase activity in sarcoplasmic reticulum vesicles than controls (n=8).
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