Key result
A 160 mg long-acting propranolol capsule produced significantly lower mean peak blood levels compared to 160 mg once daily and 80 mg twice daily standard tablets, but maintained higher levels later.
Why the study?
Does a 160 mg long-acting capsule formulation of propranolol alter whole blood concentrations compared to standard tablet regimens in healthy male volunteers?
Does a 160 mg long-acting capsule formulation of propranolol alter whole blood concentrations compared to standard tablet regimens in healthy male volunteers?
A 160 mg long-acting capsule of propranolol provides lower peak but more sustained blood concentrations compared to standard once-daily or twice-daily dosing.
Answers are grounded in this paper and cite their sources.
May support steadier propranolol levels in volunteers; leaves open clinical benefits or tolerability in patients.
I The whole blood concentrations of propranolol have been compared, over a 48 h period, in twelve healthy male volunteers dosed with a 160 mg long-acting capsule formulation (LA, United Kingdom patent application No. 23114/77) and three standard tablet regimens; 160 mg once a day (CP 160), 80 mg twice a day (CP80) and 40 mg four times a day (CP40). 2 The mean peak blood level for the long-acting formulation was significantly lower than that obtained with the 160 mg standard tablet. However, from 12 h on the mean levels for the long-acting formulation were higher. 3 The mean peak blood level for the long-acting formulation was significantly lower than that obtained with the 80 mg twice a day regimen and this difference was maintained up to 24 h. Thereafter, however, the situation was reversed. 4 The mean blood levels between 12 and 15 h were lower for the long-acting formulation when compared with the 40 mg four times a day regimen. At all other times, however, the observed levels were very similar.
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McAinsh et al. (1978) studied Healthy (n=12). Long-acting propranolol capsule vs. Standard tablet regimens (160 mg once daily, 80 mg twice daily, 40 mg four times daily) was evaluated on Whole blood concentrations of propranolol. A 160 mg long-acting propranolol capsule produced significantly lower mean peak blood levels compared to 160 mg once daily and 80 mg twice daily standard tablets, but maintained higher levels later.
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