Key result
The synthetic ryanoid 21-amino-9alpha-hydroxy-ryanodine reversibly interacts with the high-affinity ryanodine binding site on sheep cardiac Ca2+-release channels in a voltage-dependent manner.
Population
Single sheep cardiac sarcoplasmic reticulum Ca2+-release channels (ryanodine receptors)
Design
Preclinical
Authors
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May inform synthetic ryanoid design for RyR modulation; leaves open translation to human cardiac disease.
The synthetic ryanoid 21-amino-9alpha-hydroxy-ryanodine interacts reversibly with cardiac ryanodine receptors, revealing novel voltage-dependent and state-dependent binding mechanisms.
Tanna et al. (1998) studied this question. 21-amino-9alpha-hydroxy-ryanodine vs. ryanodine was evaluated on Channel function modification and binding characteristics. The synthetic ryanoid 21-amino-9alpha-hydroxy-ryanodine reversibly interacts with the high-affinity ryanodine binding site on sheep cardiac Ca2+-release channels in a voltage-dependent manner.
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