Key result
Ryanodine modifies the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by altering its affinity and relative permeability for different classes of permeant cations.
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Does not support clinical changes; leaves open ryanodine effects on human cardiac SR channels.
Lindsay et al. (1994) studied this question. Ryanodine vs. Absence of ryanodine was evaluated on Single-channel conductance and fractional conductance with different permeant cations. Ryanodine modifies the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by altering its affinity and relative permeability for different classes of permeant cations.
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