Key result
Ajmaline-induced ST (J point) elevation in the Type I Brugada ECG pattern strongly correlated with the degree of conduction delay in the right ventricular outflow tract (Pearson R 0.81, p<0.001), rather than prolongation in repolarization time.
Why the study?
Does ajmaline infusion reveal that ST elevation magnitude correlates with right ventricular outflow tract conduction delay in patients with concealed Type I Brugada syndrome?
Observational (n=13)
No
Does ajmaline infusion reveal that ST elevation magnitude correlates with right ventricular outflow tract conduction delay in patients with concealed Type I Brugada syndrome?
Effect estimate: Pearson R 0.81
p-value: p=<0.001
The magnitude of ST elevation in Type I Brugada syndrome correlates with the degree of conduction delay in the right ventricular outflow tract, supporting the depolarization hypothesis over the repolarization hypothesis.
No takes yet. Share an insight, caveat, or question.
ECGI during ajmaline challenge may delineate BrS conduction-repolarization patterns; leaves open its clinical utility for risk stratification.
Leong et al. (2017) conducted an observational in Brugada Syndrome (n=13). Ajmaline infusion vs. Baseline / Healthy controls was evaluated on Correlation between conduction delay (activation time duration) in the right ventricular outflow tract and the degree of J-ST point elevation (Pearson R 0.81, p=<0.001). Ajmaline-induced ST (J point) elevation in the Type I Brugada ECG pattern strongly correlated with the degree of conduction delay in the right ventricular outflow tract (Pearson R 0.81, p<0.001), rather than prolongation in repolarization time.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: