July 1, 1999Journal of Cardiovascular Electrophysiology
Transient Local Changes in Right Ventricular Monophasic Action Potentials Due to Ajmaline in a Patient with Brugada Syndrome
Why the study?
Does intravenous ajmaline alter right ventricular monophasic action potentials in a patient with Brugada syndrome?
Population
1 48-year-old patient with recurrent episodes of palpitations and syncope, transient ST segment elevation in…
Design
Case_report
Authors
Discussion
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Implication
Ajmaline-induced RV repolarization changes may underlie Brugada ECG patterns; single-case data leave mechanistic confirmation open.
Structured PICO
Does intravenous ajmaline alter right ventricular monophasic action potentials in a patient with Brugada syndrome?
P
Population
1 48-year-old patient with recurrent episodes of palpitations and syncope, transient ST segment elevation in the right precordial ECG leads, and no structural heart disease (Brugada syndrome)
I
Intervention
Intravenous ajmaline
O
Outcome
Changes in right ventricular (RV) monophasic action potentials (MAPs)surrogate
Intravenous ajmaline induces regionally different action potential changes in the right ventricle, which may contribute to the characteristic ECG changes seen in Brugada syndrome.
Cite This Study
ECKARDT et al. (1999) studied this question.