Key result
Adenosine triphosphate and creatine phosphate significantly increased the time for tension to be reduced by 50% during acute anoxia in isolated guinea-pig atria.
Why the study?
Do adenosine triphosphate and creatine phosphate protect isolated guinea-pig atria against acute anoxia?
Do adenosine triphosphate and creatine phosphate protect isolated guinea-pig atria against acute anoxia?
ATP and creatine phosphate protect isolated cardiac muscle against acute anoxia by delaying the loss of developed tension.
Answers are grounded in this paper and cite their sources.
May support myocardial protection in experimental anoxia; hypothesis-generating and should not change clinical practice.
A standardized and reproduceable preparation is described that enables the effect of drugs to be examined on the response of isolated cardiac muscle to acute anoxia. There was a linear relation (r = 0·963) between tension developed in isolated, electrically-driven guinea-pig atria and the oxygen tension of the fluid surrounding the muscle. For any one atrial preparation the time taken, from the beginning of the anoxic period, for tension to be reduced by 50 % was constant for consecutive anoxic periods. ATP and creatine phosphate significantly increased this time and protected cardiac muscle against the consequences of anoxia; in concentrations that were without direct cardiac effects, a greater degree of protection was possible with creatine phosphate.
No takes yet. Share an insight, caveat, or question.
Parratt et al. (1974) studied Acute anoxia in isolated cardiac muscle. Adenosine triphosphate (ATP) and creatine phosphate vs. Consecutive anoxic periods without drug was evaluated on Time taken from the beginning of the anoxic period for tension to be reduced by 50%. Adenosine triphosphate and creatine phosphate significantly increased the time for tension to be reduced by 50% during acute anoxia in isolated guinea-pig atria.
Synapse has enriched 10 related papers. Consider them for comparative context: