Key result
Patient-controlled epidural analgesia with bupivacaine and fentanyl significantly reduced mean 24-hour fentanyl consumption (243.5 mcg vs 402.5 mcg) and pain scores compared to intravenous fentanyl.
Why the study?
Does patient-controlled epidural analgesia using bupivacaine and fentanyl improve postoperative pain and reduce opioid consumption compared to intravenous fentanyl in patients undergoing abdominal surgeries?
RCT (n=60)
Randomly allocated
No
Does patient-controlled epidural analgesia using bupivacaine and fentanyl improve postoperative pain and reduce opioid consumption compared to intravenous fentanyl in patients undergoing abdominal surgeries?
Absolute Event Rate: 243.5% vs 402.5%
p-value: p=<0.001
Patient-controlled epidural analgesia with bupivacaine and fentanyl provides superior pain relief, reduces total opioid consumption, and decreases nausea compared to intermittent intravenous fentanyl after abdominal surgery.
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Epidural PCA may offer better postoperative analgesia than IV fentanyl; leaves open confirmation in larger randomized trials.
Rita Upadhyay (2017) conducted an RCT in Postoperative pain after abdominal surgeries (n=60). Patient Controlled Epidural Analgesia (PCEA) using bupivacaine and fentanyl vs. Intravenous fentanyl was evaluated on Mean fentanyl consumption at 24 hours (mcg) (p=<0.001). Patient-controlled epidural analgesia with bupivacaine and fentanyl significantly reduced mean 24-hour fentanyl consumption (243.5 mcg vs 402.5 mcg) and pain scores compared to intravenous fentanyl.
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