What question did this study set out to answer?

To measure urinary excretion of 19-nor-deoxycorticosterone in spontaneously hypertensive rats compared to normotensive controls during development prior to hypertension onset.

June 1, 1982Endocrinology

Urinary 19-Nor-Deoxycorticosterone Excretion in the Spontaneously Hypertensive Rat*

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Authors

SDSidney L. DaleBoston University MHMonika HolbrookBoston University PKPavel KomanickyWayne State University

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Implication

Animal study demonstrates elevated prehypertensive 19-nor-DOC excretion in spontaneously hypertensive rats, indicating a possible early endocrine role in hypertension development.

Key Points

To measure urinary excretion of 19-nor-deoxycorticosterone in spontaneously hypertensive rats compared to normotensive controls during development prior to hypertension onset.
Measured urinary free 19-nor-deoxycorticosterone (19-nor-DOC) excretion weekly from weaning at 3 weeks to 7 weeks of age.
Compared male and female spontaneously hypertensive rats (SHR) against normotensive Wistar Kyoto (WKY) control rats.
Urinary 19-nor-DOC excretion was significantly elevated in both male and female SHR relative to WKY controls before hypertension developed at 8 weeks of age.
Excretion levels normalized to WKY baseline 1 week earlier in male SHR than in female SHR, with female SHR levels returning to normal immediately before hypertension onset.

Cite This Study

Dale et al. (1982) studied this question.

synapsesocial.com/papers/6a939b65573827cfc84626cb https://doi.org/10.1210/endo-110-6-1989

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Implication

Animal study demonstrates elevated prehypertensive 19-nor-DOC excretion in spontaneously hypertensive rats, indicating a possible early endocrine role in hypertension development.

Urinary 19-Nor-Deoxycorticosterone Excretion in the Spontaneously Hypertensive Rat*

Discussion

Member takes

Implication

Key Points

Cite This Study

Urinary 19-Nor-Deoxycorticosterone Excretion in the Spontaneously Hypertensive Rat*

Discussion

Member takes

Implication

Key Points

Cite This Study

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