Key result
Prophylactic treatment with dextran or low-dose heparin resulted in postoperative deep vein thrombosis rates of 25% and 47%, respectively, compared to 33% in the control group.
Why the study?
Does prophylactic treatment with dextran or low dose heparin affect the incidence of deep vein thrombosis and activated factor X inhibitor activity in patients undergoing total hip replacement?
Population
60 patients undergoing total hip replacement
Comparison
Prophylactic treatment with dextran or low dose… vs Control group (no prophylactic treatment)
Design
RCT, Randomly allotted to three groups
Follow-up
Postoperative period
Authors
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Low-dose heparin increased DVT rates after hip replacement; challenges its prophylactic role and extends FXaI activity observations.
RCT (n=60)
Randomly allotted to three groups
Does prophylactic treatment with dextran or low dose heparin affect the incidence of deep vein thrombosis and activated factor X inhibitor activity in patients undergoing total hip replacement?
In patients undergoing total hip replacement, postoperative DVT is associated with a marked decrease in FXaI activity in the control group, while prophylactic heparin or dextran alters this relationship.
Welin-Berger et al. (1982) conducted an RCT in Total hip replacement (n=60). Dextran and low dose heparin vs. Control was evaluated on Postoperative deep vein thrombosis. Prophylactic treatment with dextran or low-dose heparin resulted in postoperative deep vein thrombosis rates of 25% and 47%, respectively, compared to 33% in the control group.
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